In[1]: x2
Out[1]: array([[3, 5, 2, 4],
                [7, 6, 8, 8],
                [1, 6, 7, 7]])
In[2]: x2[0, 0]
Out[2]: 3
In[3]: x2[2, 0]
Out[3]: 1
In[4]: x2[2, -1]
Out[4]: 7